Embryos develop spatiotemporal patterns by encoding and interpreting biological signals in real time. Despite unavoidable fluctuations in gene expression, embryonic development is robust and reproducible, which necessitates several mechanisms buffering stochastic gene expression. A striking example of robust spatiotemporal patterning is the rhythmic segmentation of somites, which are precursors of the vertebral column. Segmentation of somites is controlled by: 1) oscillatory expression of Hes/Her gene family, known as the vertebrate segmentation clock, 2) short-distance Notch signaling, 3) long-distance Fgf, Wnt, and Retinoic Acid signaling gradients and 4) a network of transcription factors integrating outputs of the segmentation clock and the signaling pathways. Errors in this regulatory cascade result in various birth defects, including congenital scoliosis. We combine single-cell microscopy measurements, time-resolved perturbation experiments, biophysical modeling and computational simulations to decipher the mechanism underlying robust spatiotemporal pattern formation and cell fate determination. Relevant publications: Nature 2021 589:431-436; iScience 2019 12:247-259; Cell Reports 2018 24:66-78; Cell Reports 2018 23:2175-2185.
MAJOR DUTIES AND RESPONSIBILITIES: ??? Design, execute, and record laboratory experiments, and analyze the data. ??? Research and improve current methods and evaluate innovative techniques. Implement this knowledge in the Division/Department. ??? Present research at laboratory meetings, journal clubs, seminars, and meetings. ??? Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants. ??? Maintain currency in field through continuing education, literature, and seminars. ??? Attend required Cincinnati Children's training sessions and ensure regulatory compliance with all policies and procedures. ??? Perform other duties as assigned.
Cincinnati Children's Research and Training at a Glance
Among the top in NIH funding for pediatric research institutions
Over 1.4 million square feet of research laboratory space
900+ scientists conducting basic, translational, and clinical research
Over 2000 publications annually in top-tier journals
Access to Employee Resource Groups and Mentorship programs
Postdocs have gone on to careers in academia, biotech, pharma, teaching etc.
Ph.D. in related discipline, MD, or equivalent required.
PREFERRED: Interested candidates must have a strong record of accomplishments and experience in: 1- Genetics, developmental biology, microscopy, and image analysis; OR 2- Mathematical and computational modeling, or theoretical physics
We are looking for a colleague who is highly motivated and independent.
Excellent written, verbal, and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability, and an innovative approach to experimental design. Computer literate and working knowledge of software applications (word processing, spreadsheet, and database). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analysis. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments.
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better, and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.