Location: New York, New York
Academic / Research
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The Pertsinidis lab in the Structural Biology Program of the Sloan Kettering Institute at MSKCC
has immediate openings for Postdoctoral positions.
A major focus in our lab is developing cutting-edge single-molecule detection and superresolution
optical imaging techniques. We further apply the tools we develop to visualize and
understand some of the most fundamental biological processes that power cellular life. For
example, our lab has developed modulation interferometry, a single-molecule localization-based
super-resolution technique with ~1-2 nm 3D precision and target-locking 3D nanoscopy, a
technique that achieved single-molecule detection in high background, crowded intracellular
environments. These tools have enabled some of the highest resolution single-molecule studies
to date, providing new biological insights that could not be obtained before (e.g. Wang et al. Cell
2016; Li et al., Cell 2019).
Successful applicants will become an important member of our vibrant, interdisciplinary team of
physical and biological scientists. We now develop the next-generation of low-background, noninvasive
and photon-efficient techniques - to further enhance our ability to visualize biological
processes in live cells with single-molecule sensitivity, (sub)-millisecond temporal and (sub)-
nanometer 3D spatial resolution. We also further push the limits of extracting high-resolution
information from weak signals in optically inhomogeneous, thick, multi-cellular environments,
such as tissue explants, 3D organoids and the developing embryo. Finally, we develop new
single-molecule imaging and machine learning technologies for in situ structural
biology, to enable for the first time high-resolution structural studies inside cells.
* Desire to tackle outstanding challenges in optics, microscopy and/or single-molecule
* Ph.D. degree in Physics, Chemistry, Optics, Optical Engineering, Biophysics or a
relevant scientific or engineering field.
* Ability to work effectively in a collaborative, multidisciplinary environment.
Experience with single-molecule detection instrumentation and high/super-resolution optical
imaging (e.g. STED/RESOLFT, 4Pi, MINFLUX, SIM, LLS/SPIM approaches, Adaptive Optics,
etc.), as well as cryogenic and UHV technologies is preferred but not required. Individuals with
additional working knowledge in areas of biochemistry, molecular, cell and developmental
biology and/or genetics are strongly encouraged to apply.
Please send a CV, names and contact
information of three references, and a short description of scientific interests to Dr. Alexandros
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